September, 2010
Volume 31, Issue 9

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Volume 31, Issue 9

Candida species are fungal pathogens that form part of the normal microbial flora that inhabits body surfaces. Candidiasis of the skin or mucosa is common, benign and transient in healthy individuals. But, in immunocompromised patients, infection often becomes chronic, and can disseminate to deep-tissues. On pages 346–353, Netea and Maródi dissect how pattern-recognition receptors allow innate immune cells to recognize and respond to Candida species. The cover image shows a microscopic representation of Candida albicans. Image modified from 3D4Medical.com (Photographer)/3D4Medical.com (collection)/Getty Images.



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Editorial Team

  • Editor
    Elizabeth Thompson
  • Executive Editor, Immunology
    Peter Lee
  • Journal Manager
    Sheilagh Douma
  • Journal Administrator
    Peggy Kristanto

Advisory Editorial Board

  • G. Anderson
    J.D. Ashwell
    F.R. Carbone
    M.F. Flajnik
    A.T.J. George
    B.A. Imhof
    J. Kipnis
    J.D. Lambris
    A. Mantovani
    L.M. Moretta
    G.J.V.Nossal
    P.S. Ohashi
    L.A.J. O'Neill
    R. M. Ransohoff
    C. Terhorst
    K. Wood

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Featured Article

Innate immune mechanisms for recognition and uptake of Candida species
Mihai G. Netea, and László Maródi
10.1016/j.it.2010.06.007
Abstract | |

Announcing the Inaugural Cell Symposia

Inflammation & Disease
September 26–28, 2010 | Lisbon, Portugal
Abstract submission deadline: May 17, 2010
Register Now! | Submit your abstract

Influenza
December 2–4, 2010 | Washington, DC
Abstract submission deadline: July 2, 2010
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New! Biology of Recognition

The 2010 meeting in the Exciting Biologies Series

October 7-9, 2010
Sentosa Island, Singapore
Abstracts Due: July 7, 2010
Registration Deadline: August 6th
Learn More | Register

Articles of Interest in Other Journals

Immunity
Follicular B Cell Trafficking within the Spleen Actively Restricts Humoral Immune Responses
Kristen L. Hoek, Laura E. Gordy, Patrick L. Collins, Vrajesh V. Parekh, Thomas M. Aune, Sebastian Joyce, James W. Thomas, Luc Van Kaer, and Eric Sebzda

Immunity
The Ubiquitin Modifying Enzyme A20 Restricts B Cell Survival and Prevents Autoimmunity
Rita M. Tavares, Emre E. Turer, Chih L. Liu, Rommel Advincula, Patrizia Scapini, Lesley Rhee, Julio Barrera, Clifford A. Lowell, Paul J. Utz, Barbara A. Malynn, and Averil Ma

Molecular Cell
Sin1-mTORC2 Suppresses rag and il7r Gene Expression through Akt2 in B Cells
Adam S. Lazorchak, Dou Liu, Valeria Facchinetti, Annarita Di Lorenzo, William C. Sessa, David G. Schatz, Bing Su

Trends in Parasitology
Macroparasites, innate immunity and immunoregulation: developing natural models
Ida M. Friberg, Janette E. Bradley, and Joseph A. Jackson

Supplementary Material

Special Issue: Immune senescence
(FREE ACCESS TO ARTICLES sponsored by the NIH)

Posters

Immune senescence poster
(Sponsored by the NIH)



About Trends in Immunology

Trends in Immunology publishes concise, lively and up-to-date articles that highlight advances in the diverse fields of immunology. Review and Opinion articles form the basis of each monthly issue. Review articles objectively chronicle recent and important developments in a field. Opinion articles provide a forum for debate and hypothesis. Articles are generally invited by the Editor but proposal are welcome. Proposals should be sent to the editor (immunology@elsevier.com), as a brief summary that includes key references.



In the September issue

Innate immune mechanisms for recognition and uptake of Candida species

Candida species are common fungal pathogens in humans. In this article, Netea and Maródi discuss how the host initiates an efficient antifungal immune response and describe genetic mutations in the corresponding immune pathways that lead to increased susceptibility to fungal infection.*FREE*


New views on natural killer cell-based immunotherapy for melanoma treatment

In this article, the authors review current understanding of NK cell responses against melanoma. Using this knowledge, they propose how strategies to manipulate NK cell activity might be used in immunotherapy to treat the disease at different stages of progression.


IL-17 and IL-22: siblings, not twins

Interleukin (IL)-17 and IL-22 are produced by leukocytes and act on epithelial cells to stimulate an innate immune response. Here, Schmidt-Weber and colleagues review the structural features and organ-specific effects of these cytokines.

Also in this issue:

Direct and indirect roles of the LTβR pathway in central tolerance induction

B cells and autoantibodies: complex roles in CNS injury

Click here for the complete table of contents.

Most Read Articles RSS Icon Article Feed

These are the five most downloaded papers for the 30 days preceding September 9, 2010. See full list of most read articles

LAT signaling pathology: an “autoimmune” condition without T cell self-reactivity
Romain Roncagalli, Michael Mingueneau, Claude Grégoire, Marie Malissen, Bernard Malissen
10.1016/j.it.2010.05.001
Summary | |
IL-17 and IL-22: siblings, not twins
Stefanie Eyerich, Kilian Eyerich, Andrea Cavani, Carsten Schmidt-Weber
10.1016/j.it.2010.06.004
Summary | |
Innate immune mechanisms for recognition and uptake of Candida species
Mihai G. Netea, László Maródi
10.1016/j.it.2010.06.007
Summary | |
Neutrophil kinetics in health and disease
Charlotte Summers, Sara M. Rankin, Alison M. Condliffe, Nanak Singh, A. Michael Peters, Edwin R. Chilvers
10.1016/j.it.2010.05.006
Summary | |
Early T cell development and the pitfalls of potential
Susan M. Schlenner, Hans-Reimer Rodewald
10.1016/j.it.2010.06.002
Summary | |