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These are the most downloaded papers for the 30 days preceding September 9, 2010.
| 1. | Direct Reprogramming of Fibroblasts into Functional Cardiomyocytes by Defined Factors Masaki Ieda, Ji-Dong Fu, Paul Delgado-Olguin, Vasanth Vedantham, Yohei Hayashi, Benoit G. Bruneau, Deepak Srivastava
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6 August 2010
142(3) |
| 2. | Generation of Rat Pancreas in Mouse by Interspecific Blastocyst Injection of Pluripotent Stem Cells Toshihiro Kobayashi, Tomoyuki Yamaguchi, Sanae Hamanaka, Megumi Kato-Itoh, Yuji Yamazaki, Makoto Ibata, Hideyuki Sato, Youn-Su Lee, Jo-ichi Usui, A.S. Knisely et al.
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3 September 2010
142(5) |
| 3. | Reversal of Cancer Cachexia and Muscle Wasting by ActRIIB Antagonism Leads to Prolonged Survival Xiaolan Zhou, Jin Lin Wang, John Lu, Yanping Song, Keith S. Kwak, Qingsheng Jiao, Robert Rosenfeld, Qing Chen, Thomas Boone, W. Scott Simonet et al.
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20 August 2010
142(4) |
| 4. | GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects Da Young Oh, Saswata Talukdar, Eun Ju Bae, Takeshi Imamura, Hidetaka Morinaga, WuQiang Fan, Pingping Li, Wendell J. Lu, Steven M. Watkins, Jerrold M. Olefsky
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3 September 2010
142(5) |
| 5. | A Large Intergenic Noncoding RNA Induced by p53 Mediates Global Gene Repression in the p53 Response Maite Huarte, Mitchell Guttman, David Feldser, Manuel Garber, Magdalena J. Koziol, Daniela Kenzelmann-Broz, Ahmad M. Khalil, Or Zuk, Ido Amit, Michal Rabani et al.
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6 August 2010
142(3) |
| 6. | An Alternative Splicing Network Links Cell-Cycle Control to Apoptosis Michael J. Moore, Qingqing Wang, Caleb J. Kennedy, Pamela A. Silver
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20 August 2010
142(4) |
| 7. | The Language of Histone Crosstalk Jung-Shin Lee, Edwin Smith, Ali Shilatifard
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3 September 2010
142(5) |
| 8. | Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models Lars M. Ittner, Yazi D. Ke, Fabien Delerue, Mian Bi, Amadeus Gladbach, Janet van Eersel, Heidrun Wölfing, Billy C. Chieng, MacDonald J. Christie, Ian A. Napier et al.
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6 August 2010
142(3) |
| 9. | Activation of Specific Apoptotic Caspases with an Engineered Small-Molecule-Activated Protease Daniel C. Gray, Sami Mahrus, James A. Wells
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20 August 2010
142(4) |
| 10. | Immunoproteasomes Preserve Protein Homeostasis upon Interferon-Induced Oxidative Stress Ulrike Seifert, Lukasz P. Bialy, Frédéric Ebstein, Dawadschargal Bech-Otschir, Antje Voigt, Friederike Schröter, Timour Prozorovski, Nicole Lange, Janos Steffen, Melanie Rieger et al.
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20 August 2010
142(4) |
| 11. | Structural Basis for Negative Cooperativity in Growth Factor Binding to an EGF Receptor Diego Alvarado, Daryl E. Klein, Mark A. Lemmon
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20 August 2010
142(4) |
| 12. | ATG12 Conjugation to ATG3 Regulates Mitochondrial Homeostasis and Cell Death Lilliana Radoshevich, Lyndsay Murrow, Nan Chen, Estefania Fernandez, Srirupa Roy, Christopher Fung, Jayanta Debnath
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20 August 2010
142(4) |
| 13. | Cellular Strategies for Regulating DNA Supercoiling: A Single-Molecule Perspective Daniel A. Koster, Aurélien Crut, Stewart Shuman, Mary-Ann Bjornsti, Nynke H. Dekker
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20 August 2010
142(4) |
| 14. | A Shaker K+ Channel with a Miniature Engineered Voltage Sensor Yanping Xu, Yajamana Ramu, Zhe Lu
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20 August 2010
142(4) |
| 15. | Noncoding RNAs: The Missing “Linc” in p53-Mediated Repression Anthony M. Barsotti, Carol Prives
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6 August 2010
142(3) |
| 16. | PNPASE Regulates RNA Import into Mitochondria Geng Wang, Hsiao-Wen Chen, Yavuz Oktay, Jin Zhang, Eric L. Allen, Geoffrey M. Smith, Kelly C. Fan, Jason S. Hong, Samuel W. French, J. Michael McCaffery et al.
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6 August 2010
142(3) |
| 17. | Reversing Cachexia Michael J. Tisdale
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20 August 2010
142(4) |
| 18. | SnapShot: Homologous Recombination in DNA Double-Strand Break Repair Gerard Mazón, Eleni P. Mimitou, Lorraine S. Symington |
20 August 2010
142(4) |
| 19. | The Immunoproteasome Cleans up after Inflammation Sjoerd van Deventer, Jacques Neefjes
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20 August 2010
142(4) |
| 20. | Fyn-Tau-Amyloid: A Toxic Triad Christian Haass, Eckhard Mandelkow
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6 August 2010
142(3) |
