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These are the most downloaded papers for the 30 days preceding February 4, 2012.

1. A Two-Dimensional ERK-AKT Signaling Code for an NGF-Triggered Cell-Fate Decision
 Jia-Yun Chen, Jia-Ren Lin, Karlene A. Cimprich, Tobias Meyer
Summary | |
27 January 2012
45(2)
2. Functional Association of Gdown1 with RNA Polymerase II Poised on Human Genes
 Bo Cheng, Tiandao Li, Peter B. Rahl, Todd E. Adamson, Nicholas B. Loudas, Jiannan Guo, Katayoun Varzavand, Jeffrey J. Cooper, Xiaopeng Hu, Averell Gnatt et al.
Summary | |
13 January 2012
45(1)
3. Transcriptional Regulation by Pol II(G) Involving Mediator and Competitive Interactions of Gdown1 and TFIIF with Pol II
 Miki Jishage, Sohail Malik, Ulrich Wagner, Beatrix Uberheide, Yasushi Ishihama, Xiaopeng Hu, Brian T. Chait, Averell Gnatt, Bing Ren, Robert G. Roeder
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13 January 2012
45(1)
4. Tyrosine Phosphorylation of Mitochondrial Pyruvate Dehydrogenase Kinase 1 Is Important for Cancer Metabolism
 Taro Hitosugi, Jun Fan, Tae-Wook Chung, Katherine Lythgoe, Xu Wang, Jianxin Xie, Qingyuan Ge, Ting-Lei Gu, Roberto D. Polakiewicz, Johannes L. Roesel et al.
Summary | |
23 December 2011
44(6)
5. RNase H and Postreplication Repair Protect Cells from Ribonucleotides Incorporated in DNA
 Federico Lazzaro, Daniele Novarina, Flavio Amara, Danielle L. Watt, Jana E. Stone, Vincenzo Costanzo, Peter M. Burgers, Thomas A. Kunkel, Paolo Plevani, Marco Muzi-Falconi
Summary | |
13 January 2012
45(1)
6. Polycomb Protein Ezh1 Promotes RNA Polymerase II Elongation
 Kambiz Mousavi, Hossein Zare, A. Hongjun Wang, Vittorio Sartorelli
Summary | |
27 January 2012
45(2)
7. Immobilization of Proteins in the Nucleolus by Ribosomal Intergenic Spacer Noncoding RNA
 Timothy E. Audas, Mathieu D. Jacob, Stephen Lee
Summary | |
27 January 2012
45(2)
8. How To Choose a Good Scientific Problem
 Uri Alon
Summary | |
24 September 2009
35(6)
9. SIRT1 Regulation—It Ain't All NAD
 Lily C. Chao, Peter Tontonoz
Summary | |
13 January 2012
45(1)
10. DNA Damage Signaling Triggers Degradation of Histone Methyltransferases through APC/CCdh1 in Senescent Cells
 Akiko Takahashi, Yoshinori Imai, Kimi Yamakoshi, Shinji Kuninaka, Naoko Ohtani, Shin Yoshimoto, Satoshi Hori, Makoto Tachibana, Emma Anderton, Takashi Takeuchi et al.
Summary | |
15 December 2011
11. Hydrogen Sulfide-Linked Sulfhydration of NF-κB Mediates Its Antiapoptotic Actions
 Nilkantha Sen, Bindu D. Paul, Moataz M. Gadalla, Asif K. Mustafa, Tanusree Sen, Risheng Xu, Seyun Kim, Solomon H. Snyder
Summary | |
13 January 2012
45(1)
12. Autophagy and the Integrated Stress Response
 Guido Kroemer, Guillermo Mariño, Beth Levine
Summary | |
22 October 2010
40(2)
13. Essential Features and Rational Design of CRISPR RNAs that Function with the Cas RAMP Module Complex to Cleave RNAs
 Caryn R. Hale, Sonali Majumdar, Joshua Elmore, Neil Pfister, Mark Compton, Sara Olson, Alissa M. Resch, Claiborne V.C. Glover, Brenton R. Graveley, Rebecca M. Terns et al.
Summary | |
05 January 2012
14. A Universal RNA Polymerase II CTD Cycle Is Orchestrated by Complex Interplays between Kinase, Phosphatase, and Isomerase Enzymes along Genes
 Alain R. Bataille, Célia Jeronimo, Pierre-Étienne Jacques, Louise Laramée, Marie-Ève Fortin, Audrey Forest, Maxime Bergeron, Steven D. Hanes, François Robert
Summary | |
27 January 2012
45(2)
15. Inhibition of Homologous Recombination by the PCNA-Interacting Protein PARI
 George-Lucian Moldovan, Donniphat Dejsuphong, Mark I.R. Petalcorin, Kay Hofmann, Shunichi Takeda, Simon J. Boulton, Alan D. D'Andrea
Summary | |
13 January 2012
45(1)
16. Policing Cells under Stress: Noncoding RNAs Capture Proteins in Nucleolar Detention Centers
 Kannanganattu V. Prasanth
Summary | |
27 January 2012
45(2)
17. The cAMP/PKA Pathway Rapidly Activates SIRT1 to Promote Fatty Acid Oxidation Independently of Changes in NAD+
 Zachary Gerhart-Hines, John E. Dominy, Sharon M. Blättler, Mark P. Jedrychowski, Alexander S. Banks, Ji-Hong Lim, Helen Chim, Steven P. Gygi, Pere Puigserver
Summary | |
23 December 2011
44(6)
18. H2B Ubiquitylation Controls the Formation of Export-Competent mRNP
 Adeline Vitaliano-Prunier, Anna Babour, Lucas Hérissant, Luciano Apponi, Thanasis Margaritis, Frank C.P. Holstege, Anita H. Corbett, Carole Gwizdek, Catherine Dargemont
Summary | |
13 January 2012
45(1)
19. Ser7 Phosphorylation of the CTD Recruits the RPAP2 Ser5 Phosphatase to snRNA Genes
 Sylvain Egloff, Justyna Zaborowska, Clélia Laitem, Tamás Kiss, Shona Murphy
Summary | |
13 January 2012
45(1)
20. Decapping of Long Noncoding RNAs Regulates Inducible Genes
 Sarah Geisler, Lisa Lojek, Ahmad M. Khalil, Kristian E. Baker, Jeff Coller
Summary | |
05 January 2012