27 January, 2012
Volume 45, Issue 2
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Volume 45, Issue 2
On the cover: Polycomb group (PcG) proteins have been implicated in regulating the transmission of genetic information and cellular differentiation. A PcG complex, polycomb repressive complex 2 (PRC2), is composed by the core subunits Ezh2, Suz12, and Eed. Ezh2 (Enhancer of Zeste homolog 2) is the PRC2 catalytic subunit responsible for trimethylation of lysine 27 of histone H3 (H3K27me3), an epigenetic mark associated with transcriptional repression. In Drosophila a single Enhancer of Zeste E(z) behaves either as a repressor or activator of transcription, depending on spatial and temporal cues. Mammalian genomes are comprised of two Enhancer of Zeste paralogs: Ezh2 and Ezh1. As reported by Mousavi et al. (pp. 255–262), Ezh1 is localized to regions of the genome that are occupied by RNA polymerase II (PolII) and actively transcribed. The cover illustrates how red cars with PolII license plates zoom through the E-Zh-1 express lane (indicative of PolII transcription), whereas white cars queue at the E-Zh-2 booth (signifying transcriptional repression). Image concept by V. Sartorelli and K. Mousavi. Design and artwork by A. Hoofring.
Connections
- Keystone Symposia
Epigenomics
January 17-22, 2012
Editor - Liz Gaskell - Keystone Symposia
Gene Silencing by Small RNAs
February 7-12, 2012
Editor - Miao-Chih Tsai - Keystone Symposia
Cancer and Metabolism
February 12-17, 2012
Editor - Allyson Evans
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Molecular Cell Impact Factor: 14.194
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Haase and colleagues XIAP Promotes Wnt Signaling via Gro Ubiquitylation
Lui and colleagues PKM2 Phosphorylates Protein Substrate
Lee and colleagues XIAP Promotes Wnt Signaling via Gro Ubiquitylation
Volume 45, Issue 2 | January 27, 2012
Featured Article free
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An ERK-AKT Signaling Code for Cell-Fate Decision
Cells need to integrate complex signals to make fate decisions in response to information from the environment. Using single-cell image analysis, Meyer and colleagues identify a two dimensional ERK-AKT signaling code that allows cells to balance cell population expansion with differentiation. Preview by Kumar and Collins. |
Issue Highlights
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Immobilization of Proteins by Noncoding RNAs
Lee and colleagues describe how noncoding transcripts derived from the ribosomal intergenic spacer region regulate protein mobility in response to environmental stimuli. Preview by Prasanth. |
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Polycomb Group Proteins Occupy Transcribed Chromatin Regions
Sartorelli and colleagues show that the polycomb protein, EZH1, is recruited at actively transcribed chromatin regions in skeletal muscle cells to promote transcription elongation. Preview by Riising and Helin. |
For a complete table of contents, click here.
One Year Ago ...
Selected articles from December 2010:
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 Genome-wide Polycomb-bound RNAs by Lee and colleagues.
MnSOD Activity Is Directed by Sirt3 Acetylation by Gius and colleagues. Review on The Chromatin Signaling Pathway by Smith and Shilatifard. |
All Molecular Cell articles older than one year are available free online.
FEATURED TOPIC: Autophagy
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