27 August, 2010
Volume 39, Issue 4

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Volume 39, Issue 4

On the cover: In this issue, Facchinetti et al. (595–605) report their findings from a global analysis of replication termination sites in the budding yeast Sacchormyces cerevisiase. Termination occurs at pausing sites and is assisted by the Rrm3 helicase and the Top2 topoisomerase. Their study unmasks the mechanisms controlling DNA integrity at termination zones. The cover illustrates converging replication forks (crossroads). One polymerase stalls while the other progresses thanks to Rrm3. Top2 is important in resolving the topological constraints. Artwork by Daniele Fachinetti.

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Molecular Mechanisms @ Cell Press


Cell Stem Cell
Hematopoietic Stem Cell Quiescence Promotes Error-Prone DNA Repair and Mutagenesis
Mary Mohrin, Emer Bourke, David Alexander, Matthew R. Warr, Keegan Barry-Holson, Michelle M. Le Beau, Ciaran G. Morrison, and Emmanuelle Passegué

Cell Stem Cell
A Distinctive DNA Damage Response in Human Hematopoietic Stem Cells Reveals an Apoptosis-Independent Role for p53 in Self-Renewal
Michael Milyavsky, Olga I. Gan, Magan Trottier, Martin Komosa, Ofer Tabach, Faiyaz Notta, Eric Lechman, Karin G. Hermans, Kolja Eppert, Zhanna Konovalova, Olga Ornatsky, Eytan Domany, M. Stephen Meyn, and John E. Dick

Also, check out the Preview of both papers:

Cell Stem Cell
Differential DNA Damage Response in Stem and Progenitor Cells
Jun Seita, Derrick J. Rossi, and Irving L. Weissman



Volume 39, Issue 4 | August 27, 2010


Featured Article  free

Featured Article 1 STAT3 Is Part of the Epigenetic Switch Linking Inflammation to Cancer
STAT3 is a downstream effector of IL6 that is important for cellular transformation. Struhl and colleagues show that transient expression of microRNAs activated by STAT3 is sufficient for stable transformation, indicating that STAT3 is part of an inflammatory positive feedback loop and that the link between inflammation and cancer is a complex, self-reinforcing, regulatory circuit.



Issue Highlights

Issue Highlight 1 Controlling Lysosomal Entry of Proteins through Chaperone-Mediated Autophagy (CMA)
The Cuervo group shows that GFAP and EF1a are two GTP-regulated proteins that modulate the stability of the CMA translocation complex at the lysosomal membrane. Preview by Beau and Codogno.

Issue Highlight 2 Termination of Chromosome Replication in Eukaryotes
Foiani and colleagues analyze replication termination sites in budding yeast genome-wide and provide insight into the roles of the Rrm3 helicase and the DNA toposimerase Top2. Preview by Alver and Bielinsky.

Issue Highlight 2 Telomere Protection by the Apollo Nuclease
The de Lange group describes how Apollo, a nuclease that binds to shelterin, protects chromosome ends from fusion by generating a 3' overhang at telomeres that are replicated by leading-strand DNA synthesis. Preview by Sarthy and Baumann.

For the complete listing, see the Table of Contents.

Immediate Early Publication

The Nuclear-Retained Noncoding RNA MALAT1 Regulates Alternative Splicing by Modulating SR Splicing Factor Phosphorylation
Vidisha Tripathi, Jonathan D. Ellis, Zhen Shen, David Y. Song, Qun Pan, Andrew T. Watt, Susan M. Freier, C. Frank Bennett, Alok Sharma, Paula A. Bubulya, Benjamin J. Blencowe, Supriya G. Prasanth, and Kannanganattu V. Prasanth

"Depupylation" of Prokaryotic Ubiquitin-like Protein from Mycobacterial Proteasome Substrates
Kristin E. Burns, Francisca A. Cerda-Maira, Tao Wang, Huilin Li, William R. Bishai, and K. Heran Darwin

Featured Review  free

Featured Review Gymnastics of Molecular Chaperones
Molecular chaperones help to fold and conformationally rearrange many proteins. To do so, they progress through complex conformational cycles themselves. In this Review, Matthias Mayer discusses the conformational dynamics of ATP-dependent chaperones and how these dynamics relate to their functions.

For more Review articles, see the Molecular Cell Collections.


Featured Forum  free

How To Survive and Thrive in the Mother-Mentor Marathon
Galit Lahav

For more articles in this Forum, see the Molecular Cell Collections.


Featured Topic


Featured Topic
RNA silencing pathways regulate gene expression in many organisms. We present three FREE reviews and a three-part collection of articles on (1) mechanisms of small RNA biogenesis, (2) formation of silencing complexes and target recognition, and (3) biological functions of small noncoding RNAs. Articles from Part 2 can be accessed below. Or, you can view the Complete Collection.

For more Featured Topics, see the Molecular Cell Collections.


Reviews

Posttranscriptional Regulation of MicroRNA Biogenesis in Animals *FREE REVIEW*
Haruhiko Siomi and Mikiko C. Siomi

The CRISPR System: Small RNA-Guided Defense in Bacteria and Archaea *FREE REVIEW*
Fedor V. Karginov and Gregory J. Hannon

Making RISC *FREE REVIEW*
Tomoko Kawamata and Yukihide Tomari


Part 2: Formation of Silencing Complexes and Target Recognition

In Vitro Assembly of Plant RNA-Induced Silencing Complexes Facilitated by Molecular Chaperone HSP90
Taichiro Iki, Manabu Yoshikawa, Masaki Nishikiori, Mauren C. Jaudal, Eiko Matsumoto-Yokoyama, Ichiro Mitsuhara, Tetsuo Meshi, and Masayuki Ishikawa

Hsc70/Hsp90 Chaperone Machinery Mediates ATP-Dependent RISC Loading of Small RNA Duplexes
Shintaro Iwasaki, Maki Kobayashi, Mayuko Yoda, Yuriko Sakaguchi, Susumu Katsuma, Tsutomu Suzuki, and Yukihide Tomari

Distinct Mechanisms for MicroRNA Strand Selection by Drosophila Argonautes
Katsutomo Okamura, Na Liu, and Eric C. Lai

Hierarchical Rules for Argonaute Loading in Drosophila
Benjamin Czech, Rui Zhou, Yaniv Erlich, Julius Brennecke, Richard Binari, Christians Villalta, Assaf Gordon, Norbert Perrimon, and Gregory J. Hannon

Mammalian miRNA RISC Recruits CAF1 and PABP to Affect PABP-Dependent Deadenylation
Marc R. Fabian, Géraldine Mathonnet, Thomas Sundermeier, Hansruedi Mathys, Jakob T. Zipprich, Yuri V. Svitkin, Fabiola Rivas, Martin Jinek, James Wohlschlegel, Jennifer A. Doudna, et al.

siRNA-Mediated Heterochromatin Establishment Requires HP1 and Is Associated with Antisense Transcription
Tetsushi Iida, Jun-ichi Nakayama, and Danesh Moazed

Expanding the MicroRNA Targeting Code: Functional Sites with Centered Pairing
Chanseok Shin, Jin-Wu Nam, Kyle Kai-How Farh, H. Rosaria Chiang, Alena Shkumatava, and David P. Bartel

Enhancement of the Seed-Target Recognition Step in RNA Silencing by a PIWI/MID Domain Protein
James S. Parker, Eneida A. Parizotto, Muhan Wang, S. Mark Roe, and David Barford

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