27 January, 2012
Volume 45, Issue 2

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Volume 45, Issue 2

On the cover: Polycomb group (PcG) proteins have been implicated in regulating the transmission of genetic information and cellular differentiation. A PcG complex, polycomb repressive complex 2 (PRC2), is composed by the core subunits Ezh2, Suz12, and Eed. Ezh2 (Enhancer of Zeste homolog 2) is the PRC2 catalytic subunit responsible for trimethylation of lysine 27 of histone H3 (H3K27me3), an epigenetic mark associated with transcriptional repression. In Drosophila a single Enhancer of Zeste E(z) behaves either as a repressor or activator of transcription, depending on spatial and temporal cues. Mammalian genomes are comprised of two Enhancer of Zeste paralogs: Ezh2 and Ezh1. As reported by Mousavi et al. (pp. 255–262), Ezh1 is localized to regions of the genome that are occupied by RNA polymerase II (PolII) and actively transcribed. The cover illustrates how red cars with PolII license plates zoom through the E-Zh-1 express lane (indicative of PolII transcription), whereas white cars queue at the E-Zh-2 booth (signifying transcriptional repression). Image concept by V. Sartorelli and K. Mousavi. Design and artwork by A. Hoofring.

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Haase and colleagues XIAP Promotes Wnt Signaling via Gro Ubiquitylation
Lui and colleagues PKM2 Phosphorylates Protein Substrate
Lee and colleagues XIAP Promotes Wnt Signaling via Gro Ubiquitylation



Volume 45, Issue 2 | January 27, 2012



Featured Article  free

An ERK-AKT Signaling Code for Cell-Fate Decision
Cells need to integrate complex signals to make fate decisions in response to information from the environment. Using single-cell image analysis, Meyer and colleagues identify a two dimensional ERK-AKT signaling code that allows cells to balance cell population expansion with differentiation. Preview by Kumar and Collins.

Issue Highlights

Immobilization of Proteins by Noncoding RNAs
Lee and colleagues describe how noncoding transcripts derived from the ribosomal intergenic spacer region regulate protein mobility in response to environmental stimuli. Preview by Prasanth.
Polycomb Group Proteins Occupy Transcribed Chromatin Regions
Sartorelli and colleagues show that the polycomb protein, EZH1, is recruited at actively transcribed chromatin regions in skeletal muscle cells to promote transcription elongation. Preview by Riising and Helin.

For a complete table of contents, click here.


One Year Ago ...

Selected articles from December 2010:

Genome-wide Polycomb-bound RNAs by Lee and colleagues.

MnSOD Activity Is Directed by Sirt3 Acetylation by Gius and colleagues.

Review on The Chromatin Signaling Pathway by Smith and Shilatifard.

All Molecular Cell articles older than one year are available free online.


FEATURED TOPIC: Autophagy


The autophagic response is a complex process involving lysosomal-dependent recycling of intracellular components. Here, we present a collection of reviews and articles that highlight recent advances in the signaling pathways that stimulate autophagy, the biological consequences of autophagic activation, and the mechanisms that drive this pathway.


REVIEWS

Autophagy and the Integrated Stress Response *FREE REVIEW*
by G. Kroemer, G. Mariño, and B. Levine

Regulation of Autophagy by ROS: Physiology and Pathology *FREE TiBS REVIEW*
by R. Scherz-Shouval and Z. Elazar


RESEARCH ARTICLES

Acetylation Targets the M2 Isoform of Pyruvate Kinase for Degradation through Chaperone-Mediated Autophagy and Promotes Tumor Growth
by L. Lv, D. Li, D. Zhao, R. Lin, Y. Chu, H. Zhang, Z. Zha, Y. Liu, Z. Li, Y. Xu et al.

Oncogenic Ras-Induced Expression of Noxa and Beclin-1 Promotes Autophagic Cell Death and Limits Clonogenic Survival
by M. Elgendy, C. Sheridan, G. Brumatti, and S.J. Martin

DEPTOR, an mTOR Inhibitor, Is a Physiological Substrate of SCFßTrCP E3 Ubiquitin Ligase and Regulates Survival and Autophagy
by Y. Zhao, X. Xiong, Y. Sun

mTOR Drives Its Own Activation via SCFßTrCP-Dependent Degradation of the mTOR Inhibitor DEPTOR
by D. Gao, H. Inuzuka, M.-K.M. Tan, H. Fukushima, J.W. Locasale, P. Liu, L. Wan, B. Zhai, Y.R. Chin, S. Shaik et al.

p62 Is a Key Regulator of Nutrient Sensing in the mTORC1
by A. Duran, R. Amanchy, J.F. Linares, J. Joshi, S. Abu-Baker, A. Porollo, M. Hansen, J. Moscat, M.T. Diaz-Meco

Hsp90-Cdc37 Chaperone Complex Regulates Ulk1- and Atg13-Mediated Mitophagy
by J.H. Joo, F.C. Dorsey, A. Joshi, K.M. Hennessy-Walters, K.L. Rose, K. McCastlain, J. Zhang, R. Iyengar, C. Hwa Jung, D.-F. Suen et al.

The Selective Macroautophagic Degradation of Aggregated Proteins Requires the PI3P-Binding Protein Alfy
by M. Filimonenko, P. Isakson, K.D. Finley, M. Anderson, H. Jeong, T.J. Melia, B.J. Bartlett, K.M. Myers, H.C.G. Birkeland, T. Lamark et al.

Serine 403 Phosphorylation of p62/SQSTM1 Regulates Selective Autophagic Clearance of Ubiquitinated Proteins
by G. Matsumoto, K. Wada, M. Okuno, M. Kurosawa, and N. Nukina

Identification of Regulators of Chaperone-Mediated Autophagy
by U. Bandyopadhyay, S.Sridhar, S. Kaushik, R. Kiffin, and A.M. Cuervo

Complex Inhibitory Effects of Nitric Oxide on Autophagy
by S. Sarkar, V.I. Korolchuk, M. Renna, S. Imarisio, A. Fleming, A. Williams, M. Garcia-Arencibia, C. Rose, S. Luo, B.R. Underwood et al.

The Skp2 Promoter Integrates Signaling through the NF-κB, p53, and Akt/GSK3ß Pathways to Regulate Autophagy and Apoptosis
by B. Barré and N.D. Perkins

Positive or Negative Roles of Different Cyclin-Dependent Kinase Pho85-Cyclin Complexes Orchestrate Induction of Autophagy in Saccharomyces cerevisiae
by Z. Yang, J. Geng, W.-L. Yen, K. Wang, and D.J. Klionsky

Negative Regulation of Vps34 by Cdk Mediated Phosphorylation
by T. Furuya, M. Kim, M. Lipinski, J. Li, D. Kim, T. Lu, Y. Shen, L. Rameh, B. Yankner, L.-H. Tsai et al.

Distinct Autophagosomal-Lysosomal Fusion Mechanism Revealed by Thapsigargin-Induced Autophagy Arrest
by I.G. Ganley, P.-M. Wong, N. Gammoh, and X. Jiang

Structural Basis of Atg8 Activation by a Homodimeric E1, Atg7
by N.N. Noda, K. Satoo, Y. Fujioka, H. Kumeta, K. Ogura, H. Nakatogawa, Y. Ohsumi, and F. Inagaki

Atg8 Transfer from Atg7 to Atg3: A Distinctive E1-E2 Architecture and Mechanism in the Autophagy Pathway
by A.M. Taherbhoy, S.W. Tait, S.E. Kaiser, A.H. Williams, A. Deng, A. Nourse, M. Hammel, I. Kurinov, C.O. Rock, D.R. Green et al.


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