27 January, 2012 Volume 45, Issue 2
Previews
- Policing Cells under Stress: Noncoding RNAs Capture Proteins in Nucleolar Detention Centers p141
- Cellular Signal Processing: Out of One, Many p143
- A New Role for the Polycomb Group Protein Ezh1 in Promoting Transcription p145
Articles
- Immobilization of Proteins in the Nucleolus by Ribosomal Intergenic Spacer Noncoding RNA p147
- A Universal RNA Polymerase II CTD Cycle Is Orchestrated by Complex Interplays between Kinase, Phosphatase, and Isomerase Enzymes along Genes p158
- IKKα Activation of NOTCH Links Tumorigenesis via FOXA2 Suppression p171
- Epigenetic Mechanisms of Groucho/Grg/TLE Mediated Transcriptional Repression p185
- A Two-Dimensional ERK-AKT Signaling Code for an NGF-Triggered Cell-Fate Decision p196
- SUMO-Specific Protease 1 Is Critical for Early Lymphoid Development through Regulation of STAT5 Activation p210
- Importin 7 and Exportin 1 Link c-Myc and p53 to Regulation of Ribosomal Biogenesis p222
- Regulation of KLF4 Turnover Reveals an Unexpected Tissue-Specific Role of pVHL in Tumorigenesis p233
- Scd6 Targets eIF4G to Repress Translation: RGG Motif Proteins as a Class of eIF4G-Binding Proteins p244
Short Articles
- Polycomb Protein Ezh1 Promotes RNA Polymerase II Elongation p255
- Assembly of Drosophila Centromeric Nucleosomes Requires CID Dimerization p263
Prev Issue
On the cover: Polycomb group (PcG) proteins have been implicated in regulating the transmission of genetic information and cellular differentiation. A PcG complex, polycomb repressive complex 2 (PRC2), is composed by the core subunits Ezh2, Suz12, and Eed. Ezh2 (Enhancer of Zeste homolog 2) is the PRC2 catalytic subunit responsible for trimethylation of lysine 27 of histone H3 (H3K27me3), an epigenetic mark associated with transcriptional repression. In Drosophila a single Enhancer of Zeste E(z) behaves either as a repressor or activator of transcription, depending on spatial and temporal cues. Mammalian genomes are comprised of two Enhancer of Zeste paralogs: Ezh2 and Ezh1. As reported by Mousavi et al. (pp. 255–262), Ezh1 is localized to regions of the genome that are occupied by RNA polymerase II (PolII) and actively transcribed. The cover illustrates how red cars with PolII license plates zoom through the E-Zh-1 express lane (indicative of PolII transcription), whereas white cars queue at the E-Zh-2 booth (signifying transcriptional repression). Image concept by V. Sartorelli and K. Mousavi. Design and artwork by A. Hoofring.
