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Volume 140, Issue 2
On the cover: Unrepaired DNA double-strand breaks cause chromosome breakage and fragmentation. Chromosome fragments that do not contain a centromere cannot attach to the mitotic spindle and would segregate inappropriately during mitosis, potentially causing genomic instability. However, Royou et al. (pp. 235–245) now show that chromosome fragments can properly segregate in mitosis but rely on DNA tethers to maintain a connection with a centromere-containing sister chromosome. These DNA tethers enable the proper segregation of sister fragments to opposing poles during mitosis, thus preventing the production of daughter cells with chromosomal instability. The cover image shows a 20 s time lapse of a cell in anaphase, with a DNA tether shown in red and chromosomes in blue.
Articles in Other Cell Press Journals
- Molecular Cell
- A Genetic Screen Identifies FAN1, a Fanconi Anemia-Associated Nuclease Necessary for DNA Interstrand Crosslink Repair
- Agata Smogorzewska, Rohini Desetty, Takamune T. Saito, Michael Schlabach, Francis P. Lach, Mathew E. Sowa, Alan B. Clark, Thomas A. Kunkel, J. Wade Harper, Monica P. Colaiácovo, Stephen J. Elledge
- Cell Host & Microbe
- Cellular Networks Involved in the Influenza Virus Life Cycle
- Tokiko Watanabe, Shinji Watanabe, Yoshihiro Kawaoka
- Cell Host & Microbe
- Influenza Virus Evolution, Host Adaptation, and Pandemic Formation
- Jeffery K. Taubenberger, John C. Kash
Leading Edge
- In This Issue p163
- Molecular Medicine Select p167
Analysis
- Driving Innovation: Ready, Set, Go! p171
- Amy Maxmen
Previews
- Blocking the Deadly Effects of the NMDA Receptor in Stroke p174
- Henry G.S. Martin, Yu Tian Wang
- Forever Young p176
- Leonard Guarente
- Duct Tape for Broken Chromosomes p178
- Gary J. Gorbsky
- The Brothers RAF p180
- Lawrence N. Kwong, Lynda Chin
Review
- Chaperoning Histones during DNA Replication and Repair p183
- Monica Ransom, Briana K. Dennehey, Jessica K. Tyler
Articles
- Dietary and Genetic Obesity Promote Liver Inflammation and Tumorigenesis by Enhancing IL-6 and TNF Expression p197
- Eek Joong Park, Jun Hee Lee, Guann-Yi Yu, Guobin He, Syed Raza Ali, Ryan G. Holzer, Christoph H. Österreicher, Hiroyuki Takahashi, Michael Karin
- Kinase-Dead BRAF and Oncogenic RAS Cooperate to Drive Tumor Progression through CRAF p209
- Sonja J. Heidorn, Carla Milagre, Steven Whittaker, Arnaud Nourry, Ion Niculescu-Duvas, Nathalie Dhomen, Jahan Hussain, Jorge S. Reis-Filho, Caroline J. Springer, Catrin Pritchard, Richard Marais
- DAPK1 Interaction with NMDA Receptor NR2B Subunits Mediates Brain Damage in Stroke p222
- Weihong Tu, Xin Xu, Lisheng Peng, Xiaofen Zhong, Wenfeng Zhang, Mangala M. Soundarapandian, Cherine Balel, Manqi Wang, Nali Jia, Wen Zhang, Frank Lew, Sic Lung Chan, Yanfang Chen, Youming Lu
- BubR1- and Polo-Coated DNA Tethers Facilitate Poleward Segregation of Acentric Chromatids p235
- Anne Royou, Mary E. Gagou, Roger Karess, William Sullivan
- Structural and Energetic Mechanisms of Cooperative Autoinhibition and Activation of Vav1 p246
- Bingke Yu, Ilídio R.S. Martins, Pilong Li, Gaya K. Amarasinghe, Junko Umetani, Martin E. Fernandez-Zapico, Daniel D. Billadeau, Mischa Machius, Diana R. Tomchick, Michael K. Rosen
- The Polarisome Is Required for Segregation and Retrograde Transport of Protein Aggregates p257
- Beidong Liu, Lisa Larsson, Antonio Caballero, Xinxin Hao, David Öling, Julie Grantham, Thomas Nyström
- Autocrine VEGF Signaling Synergizes with EGFR in Tumor Cells to Promote Epithelial Cancer Development p268
- Beate M. Lichtenberger, Poi Kiang Tan, Heide Niederleithner, Napoleone Ferrara, Peter Petzelbauer, Maria Sibilia
- The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α p280
- Lei Zhong, Agustina D'Urso, Debra Toiber, Carlos Sebastian, Ryan E. Henry, Douangsone D. Vadysirisack, Alexander Guimaraes, Brett Marinelli, Jakob D. Wikstrom, Tomer Nir, Clary B. Clish, Bhavapriya Vaitheesvaran, Othon Iliopoulos, Irwin Kurland, Yuval Dor, Ralph Weissleder, Orian S. Shirihai, Leif W. Ellisen, Joaquin M. Espinosa, Raul Mostoslavsky
SnapShot
- SnapShot: Bacterial Appendages II p294
- Ana Toste Rego, Rémi Fronzes, Gabriel WaksmanPDF (1319 kb)
