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Volume 140, Issue 1

On the cover: In eukaryotes, noncoding microRNAs (miRNAs) can inhibit translation of target mRNAs via binding to complementary sequences in the target, and miRNAs thus control gene expression at the posttranscriptional level. In this issue, Khraiwesh et al. (pp. 111–122) show that in the moss Physcomitrella patens miRNAs can also regulate gene expression at the transcriptional level as they find that miRNA:target-RNA duplexes direct DNA methylation and transcriptional silencing. On the cover, this process is captured in a cartoon, showing leafy structures of the moss, where a gang of “Mafia” type miRNAs literally silence a DNA molecule by cementing it in methylation marks. Image concept by C. Bächtle and R. Kindervater, BIOPRO Baden-Württemberg GmbH, Stuttgart. Design and artwork by M. Meier and H. Rall.

Articles in Other Cell Press Journals

Molecular Cell
A Genetic Screen Identifies FAN1, a Fanconi Anemia-Associated Nuclease Necessary for DNA Interstrand Crosslink Repair
Agata Smogorzewska, Rohini Desetty, Takamune T. Saito, Michael Schlabach, Francis P. Lach, Mathew E. Sowa, Alan B. Clark, Thomas A. Kunkel, J. Wade Harper, Monica P. Colaiácovo, Stephen J. Elledge
Summary | Full Text | PDF (2378 kb)
Cell Host & Microbe
Cellular Networks Involved in the Influenza Virus Life Cycle
Tokiko Watanabe, Shinji Watanabe, Yoshihiro Kawaoka
Summary | Full Text | PDF (930 kb) | Supplemental Data
Cell Host & Microbe
Influenza Virus Evolution, Host Adaptation, and Pandemic Formation
Jeffery K. Taubenberger, John C. Kash
Summary | Full Text | PDF (530 kb)

Leading Edge

In This Issue p1
Full Text | PDF (346 kb)
Synthetic Biology Select p5
Summary | Full Text | PDF (256 kb)

Editorial

2010: A Publishing Odyssey p9
Emilie Marcus
Full Text | PDF (45 kb)

Analysis

Stem Cell Therapies: California Dreamin'? p10
Kris Novak
Summary | Full Text | PDF (214 kb)

Essays

Making Cellular Memories p13
Devin R. Burrill, Pamela A. Silver
Summary | Full Text | PDF (775 kb)
Engineering Static and Dynamic Control of Synthetic Pathways p19
William J. Holtz, Jay D. Keasling
Summary | Full Text | PDF (520 kb)

Previews

Aire, Master of Many Trades p24
Bruno Kyewski, Pärt Peterson
Summary | Full Text | PDF (698 kb)
Plant Chromatin Feels the Heat p26
Keara A. Franklin
Summary | Full Text | PDF (376 kb)
Chewing the Fat on Tumor Cell Metabolism p28
Jessica L. Yecies, Brendan D. Manning
Summary | Full Text | PDF (316 kb)
MicroTUB(B3)ules and Brain Development p30
Karun K. Singh, Li-Huei Tsai
Summary | Full Text | PDF (256 kb)

Review

Engineering Signal Transduction Pathways p33
Christina Kiel, Eva Yus, Luis Serrano
Summary | Full Text | PDF (2400 kb)

Articles

Monoacylglycerol Lipase Regulates a Fatty Acid Network that Promotes Cancer Pathogenesis p49
Daniel K. Nomura, Jonathan Z. Long, Sherry Niessen, Heather S. Hoover, Shu-Wing Ng, Benjamin F. Cravatt
Summary | Full Text
Biological and Molecular Heterogeneity of Breast Cancers Correlates with Their Cancer Stem Cell Content p62
Salvatore Pece, Daniela Tosoni, Stefano Confalonieri, Giovanni Mazzarol, Manuela Vecchi, Simona Ronzoni, Loris Bernard, Giuseppe Viale, Pier Giuseppe Pelicci, Pier Paolo Di Fiore
Summary | Full Text
Human TUBB3 Mutations Perturb Microtubule Dynamics, Kinesin Interactions, and Axon Guidance p74
Max A. Tischfield, Hagit N. Baris, Chen Wu, Guenther Rudolph, Lionel Van Maldergem, Wei He, Wai-Man Chan, Caroline Andrews, Joseph L. Demer, Richard L. Robertson, David A. Mackey, Jonathan B. Ruddle, Thomas D. Bird, Irene Gottlob, Christina Pieh, Elias I. Traboulsi, Scott L. Pomeroy, David G. Hunter, Janet S. Soul, Anna Newlin, Louise J. Sabol, Edward J. Doherty, Clara E. de Uzcátegui, Nicolas de Uzcátegui, Mary Louise Z. Collins, Emin C. Sener, Bettina Wabbels, Heide Hellebrand, Thomas Meitinger, Teresa de Berardinis, Adriano Magli, Costantino Schiavi, Marco Pastore-Trossello, Feray Koc, Agnes M. Wong, Alex V. Levin, Michael T. Geraghty, Maria Descartes, Maree Flaherty, Robyn V. Jamieson, H.U. Møller, Ingo Meuthen, David F. Callen, Janet Kerwin, Susan Lindsay, Alfons Meindl, Mohan L. Gupta, David Pellman, Elizabeth C. Engle
Summary | Full Text
Mutations in Potassium Channel Kir2.6 Cause Susceptibility to Thyrotoxic Hypokalemic Periodic Paralysis p88
Devon P. Ryan, Magnus R. Dias da Silva, Tuck Wah Soong, Bertrand Fontaine, Matt R. Donaldson, Annie W.C. Kung, Wallaya Jongjaroenprasert, Mui Cheng Liang, Daphne H.C. Khoo, Jin Seng Cheah, Su Chin Ho, Harold S. Bernstein, Rui M.B. Maciel, Robert H. Brown, Louis J. Ptáček
Summary | Full Text
A Region of the Human HOXD Cluster that Confers Polycomb-Group Responsiveness p99
Caroline J. Woo, Peter V. Kharchenko, Laurence Daheron, Peter J. Park, Robert E. Kingston
Summary | Full Text
Transcriptional Control of Gene Expression by MicroRNAs p111
Basel Khraiwesh, M. Asif Arif, Gotelinde I. Seumel, Stephan Ossowski, Detlef Weigel, Ralf Reski, Wolfgang Frank
Summary | Full Text
Aire's Partners in the Molecular Control of Immunological Tolerance p123
Jakub Abramson, Matthieu Giraud, Christophe Benoist, Diane Mathis
Summary | Full Text
H2A.Z-Containing Nucleosomes Mediate the Thermosensory Response in Arabidopsis p136
S. Vinod Kumar, Philip A. Wigge
Summary | Full Text

Resource

Drosophila Genome-wide Obesity Screen Reveals Hedgehog as a Determinant of Brown versus White Adipose Cell Fate p148
J. Andrew Pospisilik, Daniel Schramek, Harald Schnidar, Shane J.F. Cronin, Nadine T. Nehme, Xiaoyun Zhang, Claude Knauf, Patrice D. Cani, Karin Aumayr, Jelena Todoric, Martina Bayer, Arvand Haschemi, Vijitha Puviindran, Krisztina Tar, Michael Orthofer, G. Gregory Neely, Georg Dietzl, Armen Manoukian, Martin Funovics, Gerhard Prager, Oswald Wagner, Dominique Ferrandon, Fritz Aberger, Chi-chung Hui, Harald Esterbauer, Josef M. Penninger
Summary | Full Text

SnapShot

SnapShot: Bacterial Appendages I p162
Ana Toste Rego, Rémi Fronzes, Gabriel Waksman
PDF (1299 kb)