27 August, 2010
Volume 33, Issue 2

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Volume 33, Issue 2

On the cover: Neutrophils are powerfully destructive cells that, when drawn into sites of sterile inflammation, aggressively destroy normal structures. Neutrophil recruitment into tissue, therefore, is a very tightly regulated process. Although there are many chemoattractants for neutrophils, how these different mediators regulate the entry of neutrophils into tissue is not understood. Chou et al. (pages 266–278) use a murine model of autoantibody-induced arthritis to uncover an integrated model describing the complex regulation of neutrophil trafficking in vivo. The cover depicts (by different colors) a cascade of mediators that include the lipid, leukotriene B4, the cytokine, interleukin-1, and chemokines, CXCL1, CXCL2, CXCL5, CCL3, and CCL5, that sequentially collaborate to control the entry of neutrophils into the joint and induce inflammatory erosive arthritis. Cover art by Steven Moskowitz. Preview by McDonald and Kubes (pages 148–149).

One year ago ...

Selected articles from a year ago.

Medzhitov revisited the classic article "Approaching the Asymptote" on its 20th anniversary.

Powell and colleagues examined the involvement of mTOR kinase in Treg cell commitment.

All archived articles older than one year are available free online.

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Free Poster: Cross-regulation of Signaling Pathways by Interferon-γ

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Immunity Impact Factor
20.589*
* 2009 Journal Citation Reports©, published by Thomson Reuters

The Inaugural Cell Symposia

Inflammation & Disease

September 26–28, 2010
Lisbon, Portugal
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Influenza

December 2–4, 2010
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The 2010 Meeting in the Exciting Biologies Series

October 7–9, 2010
Sentosa Island, Singapore
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Current Issue

Featured articles (free):

Lipid-cytokine-chemokine cascade recruits neutrophils

Article by Luster and colleagues. Preview by McDonald and Kubes.

Interleukin-2 receptor signaling
Review by Malek and Castro.

Next issue: September 24, 2010



Also In This Issue

Winau
α-galactosidase controls self-lipid generation for NKT cells

Article by Winau and colleagues. Preview by Van Kaer and Joyce.

Powrie
IL-23 acts directly on T cells to cause intestinal inflammation

Article by Powrie and colleagues. Preview by Huber and Flavell.

Bopp
IRF4 is essential for Th9 cell development

Article by Bopp and colleagues. Preview by Veldhoen.

Xue
TCF-1 is important for memory T cell generation and maintenance

Article by Xue and colleagues. Preview by Paley and Wherry.


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