On the cover: Neutrophils are powerfully destructive cells that, when drawn into sites of sterile inflammation, aggressively destroy normal structures. Neutrophil recruitment into tissue, therefore, is a very tightly regulated process. Although there are many chemoattractants for neutrophils, how these different mediators regulate the entry of neutrophils into tissue is not understood. Chou et al. (pages 266–278) use a murine model of autoantibody-induced arthritis to uncover an integrated model describing the complex regulation of neutrophil trafficking in vivo. The cover depicts (by different colors) a cascade of mediators that include the lipid, leukotriene B
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Medzhitov revisited the classic article "Approaching the Asymptote" on its 20th anniversary.
Powell and colleagues examined the involvement of mTOR kinase in Treg cell commitment.
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Immunity Impact Factor
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* 2009 Journal Citation Reports©, published by Thomson Reuters
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Basophils Orchestrate Chronic Allergic Dermatitis and Protective Immunity against Helminths
Caspar Ohnmacht, Christian Schwartz, … , and David Voehringer
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