27 January, 2012 Volume 36, Issue 1
Previews
- NK Cell Genesis: A Trick of the Trail p1
- Fueling Memories p3
- The Aryl Hydrocarbon Receptor: A Sentinel Safeguarding the Survival of Immune Cells in the Gut p5
- Tracking Interferon in Autoimmunity p7
- The Numerology of T Cell Functional Diversity p10
Review
- B-1 B Cell Development in the Fetus and Adult p13
Articles
- Transcription of Il17 and Il17f Is Controlled by Conserved Noncoding Sequence 2 p23
- Syk Kinase-Coupled C-type Lectin Receptors Engage Protein Kinase C-δ to Elicit Card9 Adaptor-Mediated Innate Immunity p32
- TAK1 Negatively Regulates NF-κB and p38 MAP Kinase Activation in Gr-1+CD11b+ Neutrophils p43
- The Transcription Factors T-bet and Eomes Control Key Checkpoints of Natural Killer Cell Maturation p55
- Mitochondrial Respiratory Capacity Is a Critical Regulator of CD8+ T Cell Memory Development p68
- αβ T Cell Receptors that Do Not Undergo Major Histocompatibility Complex-Specific Thymic Selection Possess Antibody-like Recognition Specificities p79
- The Aryl Hydrocarbon Receptor Regulates Gut Immunity through Modulation of Innate Lymphoid Cells p92
- Notch Activation by the Metalloproteinase ADAM17 Regulates Myeloproliferation and Atopic Barrier Immunity by Suppressing Epithelial Cytokine Synthesis p105
- Autoimmunity Initiates in Nonhematopoietic Cells and Progresses via Lymphocytes in an Interferon-Dependent Autoimmune Disease p120
- RAE1ε Ligand Expressed on Pancreatic Islets Recruits NKG2D Receptor-Expressing Cytotoxic T Cells Independent of T Cell Receptor Recognition p132
Resource
- Cytometry by Time-of-Flight Shows Combinatorial Cytokine Expression and Virus-Specific Cell Niches within a Continuum of CD8+ T Cell Phenotypes p142
Erratum
- TAK1 Negatively Regulates NF-κB and p38 MAP Kinase Activation in Gr-1+CD11b+ Neutrophils p153
Prev Issue
On the cover: Mitochondria are central to the metabolic state of a cell. van der Windt et al. (pages 68–78) show that mitochondrial respiratory capacity is pivotal in the survival of T cells after infection and in the subsequent development and response of memory T cells. The cover shows a stylized image of epifluorescence staining of CD8+ T cells in which mitochondria are stained with mitotracker red (accumulates in respiring mitochondria), mitotracker green (stains mitochondrial mass), or JC-1 (fluoresces green or red, when membrane potential is low or high, respectively). The diverse pattern of mitochondrial staining indicates the heterogeneity of these organelles. Original confocal images by Mike Tighe. Image was stylized by Rianne van der Windt and Erika Pearce.
