8 September, 2010
Volume 12, Issue 3

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Volume 12, Issue 3

On the cover: Insulin regulates glucose uptake through recruitment of the Glut4 transporter to the plasma membrane. On pp. 250–259 of this issue, Zimmerberg et al. show that insulin not only stimulates exocytosis of Glut4 vesicles, but also controls its dispersal and spatial redistribution on the cell surface. The cover art is a cuboidal montage of confocal microscopy and time frame images generated from adipocytes. The top panel highlights Glut4 (red) and lipid droplets (green). The lower left panel shows Glut4 (red) and tubulin (green). The lower right panel illustrates fusion and dispersal of Glut4-storage vesicles (red) and IRAP-pHluorin (green).

NEW!

Presubmission Queries

  • If you would like editorial input on whether your paper might be a strong candidate for consideration for Cell Metabolism, you can send a presubmission inquiry using our online inquiry form.

Announcing the Inaugural Cell Symposium

Inflammation & Disease
September 26-28, 2010
Lisbon, Portugal
Abstract submission deadline: June 1, 2010
Register Now! Submit Your Abstract!

New! LabLinks

Cellular Metabolism and Cancer
Friday, September 10, 2010
Broad Institute, Cambridge, MA
Registration is free!

Announcement

Cell Metabolism congratulates Editorial Board member Roger D. Cone on his election to the National Academy of Sciences.



Cell Press Podcast

In our August podcast, we hear from H.Q. Han about a strategy to reverse the muscle wasting that accompanies cancer (00:55). Next, Owen Sansom discusses a kinase that is a key regulator of gut regeneration in health and disease (7:42). And stay tuned as Ben Cravatt discusses new insights into brain metabolism (14:02).

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Current Issue

Volume 12, Issue 3: September 8, 2010
Next issue: October 6, 2010


Online Ahead of Print

MicroRNAs Involved in Molecular Circuitries Relevant for the Duchenne Muscular Dystrophy Pathogenesis Are Controlled by the Dystrophin/nNOS Pathway

Davide Cacchiarelli, Julie Martone, Erika Girardi, Marcella Cesana, Tania Incitti, Mariangela Morlando, Carmine Nicoletti, Tiziana Santini, Olga Sthandier, Laura Barberi, Alberto Auricchio, Antonio Musarò, and Irene Bozzoni
10.1016/j.cmet.2010.07.008


In This Issue: Previews

Ferrit(in)ing Out New Mechanisms in Iron Homeostasis
Nancy C. Andrews
10.1016/j.cmet.2010.08.011
Links to Vanoaica et al.

Assembling Complex I with ACAD9
Immo E. Scheffler
10.1016/j.cmet.2010.08.008
Links to Nouws et al.

Featured Article  free

The Featured Article is freely available to all readers.

Sort1, Encoded by the Cardiovascular Risk Locus 1p13.3, Is a Regulator of Hepatic Lipoprotein Export

Kjolby et al.

Recent genome-wide association studies (GWAS) have revealed strong association of hypercholesterolemia and myocardial infarction with SNPs on human chromosome 1p13.3. This locus covers three genes: SORT1, CELSR2, and PSRC1. We demonstrate that sortilin, encoded by SORT1, is an intracellular sorting receptor for apolipoprotein (apo) B100. It interacts with apoB100 in the Golgi and facilitates the formation and hepatic export of apoB100-containing lipoproteins, thereby regulating plasma low-density lipoprotein (LDL) cholesterol. Absence of sortilin in gene-targeted mice reduces secretion of lipoproteins from the liver and ameliorates hypercholesterolemia and atherosclerotic lesion formation in LDL receptor-deficient animals. In contrast, sortilin overexpression stimulates hepatic release of lipoproteins and increases plasma LDL levels. Our data have uncovered a regulatory pathway in hepatic lipoprotein export and suggest a molecular explanation for the cardiovascular risk being associated with 1p13.3.


In This Issue: Articles

Hepatic-Specific Disruption of SIRT6 in Mice Results in Fatty Liver Formation Due to Enhanced Glycolysis and Triglyceride Synthesis
Kim et al.
Interleukin-6 Signaling in Liver-Parenchymal Cells Suppresses Hepatic Inflammation and Improves Systemic Insulin Action
Wunderlich et al.
Insulin-like Signaling Determines Survival during Stress via Posttranscriptional Mechanisms in C. elegans
McColl et al.
Rescue of Obesity-Induced Infertility in Female Mice due to a Pituitary-Specific Knockout of the Insulin Receptor
Brothers et al.