Cell Metabolism

4 January, 2012
Volume 15, Issue 1

Volume 15, Issue 1

On the cover: Adult somatic stem cells (SSCs) are involved in tissue renewal. On pp. 100–109 of this issue, Ahlqvist et al. show that subtle ROS/redox changes, induced by mtDNA mutagenesis, modulate SSC function and contribute to premature aging-related phenotypes. The cover image is a cultured mouse neural stem cell sphere covered by a network of differentiated neurons (green neuronal Tuj1 staining). Nuclei are in blue.

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In The News

Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans
Timmers et al.
November 2 issue

Coverage in: ABC News, The Guardian, The Huffington Post, The Daily Mail, MSN, Nature, UPI, Time, US News, USA Today, Washington Post, Star Tribune, WebMD, CBS News, Wine Spectator, and The Daily Telegraph

Cell Metabolism Editors @ Conferences

Nikla Emambokus
Keystone Obesity and Diabetes
Jan 29-Feb 3, 2012
Santa Fe

Anne Granger
Keystone Cancer Metabolism
Feb 12-15, 2012
Banff

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Cell Metabolism Welcomes
New Editorial Board Members

Nancy Andrews, Duke University
Christopher Newgard, Duke University
Takashi Kadowaki, The University of Tokyo
Jerrold Olefsky, UCSD
Martin Myers, University of Michigan
Rudolf Zechner, Karl Franzens University Graz
Jeffrey Gordon, Washington University in St. Louis
Diane Mathis, Harvard University
Gökhan Hotamisligil, Harvard University
Ana Maria Cuervo, Albert Einstein College of Medicine
Philipp Scherer, UTSW

Articles of Interest across Cell Press

Molecular Cell, 23 December 2011
The cAMP/PKA Pathway Rapidly Activates SIRT1 to Promote Fatty Acid Oxidation Independently of Changes in NAD⁺
Zachary Gerhart-Hines, John E. Dominy, Sharon M. Blättler, Mark P. Jedrychowski, Alexander S. Banks, Ji-Hong Lim, Helen Chim, Steven P. Gygi, Pere Puigserver

Cell, 23 December 2011
SIRT1 Activates MAO-A in the Brain to Mediate Anxiety and Exploratory Drive
Sergiy Libert, Kelli Pointer, Eric L. Bell, Abhirup Das, Dena E. Cohen, John M. Asara, Karen Kapur, Sven Bergmann, Martin Preisig, Takeshi Otowa et al.

Molecular Cell, 23 December 2011
Tyrosine Phosphorylation of Mitochondrial Pyruvate Dehydrogenase Kinase 1 Is Important for Cancer Metabolism
Taro Hitosugi, Jun Fan, Tae-Wook Chung, Katherine Lythgoe, Xu Wang, Jianxin Xie, Qingyuan Ge, Ting-Lei Gu, Roberto D. Polakiewicz, Johannes L. Roesel et al.

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Publishing with Cell Press

Online Now

Cell Metabolism is now publishing papers online in advance of the print version of the journal. Watch this space every Thursday for new articles or updates on the coming issue.

Loss of Autophagy in Pro-opiomelanocortin Neurons Perturbs Axon Growth and Causes Metabolic Dysregulation
Bérengère Coupé, Yuko Ishii, Marcelo O. Dietrich, Masaaki Komatsu, Tamas L. Horvath, and Sebastien G. Bouret

Central Nervous System Mechanisms Linking the Consumption of Palatable High-Fat Diets to the Defense of Greater Adiposity
Karen K. Ryan, Stephen C. Woods, and Randy J. Seeley

AgRP and POMC Neurons Are Hypophysiotropic and Coordinately Regulate Multiple Endocrine Axes in a Larval Teleost
Chao Zhang, Paul M. Forlano, and Roger D. Cone

Current Issue, Volume 15, Issue 1: January 4, 2012

On the Cover

Adult somatic stem cells (SSCs) are involved in tissue renewal. On pp. 100-109 of this issue, Ahlqvist et al. show that subtle ROS/redox changes, induced by mtDNA mutagenesis, modulate SSC function and contribute to premature aging-related phenotypes. The cover image is a cultured mouse neural stem cell sphere covered by a network of differentiated neurons (green neuronal Tuj1 staining). Nuclei are in blue.

Next issue: February 8, 2012

In This Issue: Previews

Reactive Oxygen Species Resulting from Mitochondrial Mutation Diminishes Stem and Progenitor Cell Function
B.S. Garrison and D.J. Rossi
Links to Ahlqvist et al.

Featured Article free

The Featured Article is freely available to all readers.

p53-Induced Adipose Tissue Inflammation Is Critically Involved in the Development of Insulin Resistance in Heart Failure

I. Shimizu, Y. Yoshida, T. Katsuno, ... I. Komuro, Y. Kobayashi, and T. Minamino

Heart failure and insulin resistance are often associated. Shimizu et al. show that, in mouse models of heart failure, activation of the sympathetic nervous system promotes lipolysis to upregulate p53 in adipose tissue, leading to inflammation and insulin resistance.

In This Issue: Articles

	Srf-Dependent Paracrine Signals Produced by Myofibers Control Satellite Cell-Mediated Skeletal Muscle Hypertrophy A. Guerci, C. Lahoute, S. Hébrard, ... D. Tuil, D. Daegelen, and A. Sotiropoulos
	PGRN is a Key Adipokine Mediating High Fat Diet-Induced Insulin Resistance and Obesity through IL-6 in Adipose Tissue T. Matsubara, A. Mita, K. Minami, ... E.-i. Matsuo, O. Nishimura, and S. Seino
	Lysosome-Related Organelles in Intestinal Cells Are a Zinc Storage Site in C. elegans H.C. Roh, S. Collier, J. Guthrie, J.D. Robertson, and K. Kornfeld
	Coordination of Triacylglycerol and Cholesterol Homeostasis by DHR96 and the Drosophila LipA Homolog magro M.H. Sieber and C.S. Thummel

Cell Metabolism Resource Articles

Resource Articles highlight significant technical advances and/or major informational databases that are of value and interest to the broad Cell Metabolism readership, and help start addressing important questions in a variety of biomedical research areas.

The mtDNA Mutation Spectrum of the Progeroid Polg Mutator Mouse Includes Abundant Control Region Multimers
Siôn L. Williams, Jia Huang, Yvonne J.K. Edwards, Rick H. Ulloa, Lloye M. Dillon, Tomas A. Prolla, Jeffery M. Vance, Carlos T. Moraes, Stephan Züchner

Molecular Annotation of Integrative Feeding Neural Circuits
Cristian A. Pérez, Sarah A. Stanley, Robert W. Wysocki, Jana Havranova, Rebecca Ahrens-Nicklas, Frances Onyimba, Jeffrey M. Friedman

Measurement of H₂O₂ within Living Drosophila during Aging Using a Ratiometric Mass Spectrometry Probe Targeted to the Mitochondrial Matrix
Helena M. Cochemé, Caroline Quin, Stephen J. McQuaker, Filipe Cabreiro, Angela Logan, Tracy A. Prime, Irina Abakumova, Jigna V. Patel, Ian M. Fearnley, Andrew M. James, Carolyn M. Porteous, Robin A.J. Smith, Saima Saeed, Jane E. Carré, Mervyn Singer, David Gems, Richard C. Hartley, Linda Partridge, Michael P. Murphy

A Fluorescent Reporter of AMPK Activity and Cellular Energy Stress
Peiling Tsou, Bin Zheng, Chia-Hsien Hsu, Atsuo T. Sasaki, Lewis C. Cantley

Mitochondrial Matrix Calcium Is an Activating Signal for Hormone Secretion
Andreas Wiederkehr, Gergõ Szanda, Dmitry Akhmedov, Chikage Mataki, Claus W. Heizmann, Kristina Schoonjans, Tullio Pozzan, András Spät, Claes B. Wollheim

¹³C-Pyruvate Imaging Reveals Alterations in Glycolysis that Precede c-Myc-Induced Tumor Formation and Regression
Simon Hu, Asha Balakrishnan, Robert A. Bok, Brittany Anderton, Peder E.Z. Larson, Sarah J. Nelson, John Kurhanewicz, Daniel B. Vigneron, Andrei Goga

Imaging Cytosolic NADH-NAD⁺ Redox State with a Genetically Encoded Fluorescent Biosensor
Yin Pun Hung, John G. Albeck, Mathew Tantama, Gary Yellen

Genetically Encoded Fluorescent Sensors for Intracellular NADH Detection
Yuzheng Zhao, Jing Jin, Qingxun Hu, Hai-Meng Zhou, Jing Yi, Zhenhang Yu, Lei Xu, Xue Wang, Yi Yang, Joseph Loscalzo

Please see also our previous Featured Topics