On the cover: Adult somatic stem cells (SSCs) are involved in tissue renewal. On pp. 100–109 of this issue, Ahlqvist et al. show that subtle ROS/redox changes, induced by mtDNA mutagenesis, modulate SSC function and contribute to premature aging-related phenotypes. The cover image is a cultured mouse neural stem cell sphere covered by a network of differentiated neurons (green neuronal Tuj1 staining). Nuclei are in blue.

Nancy Andrews, Duke University
Christopher Newgard, Duke University
Takashi Kadowaki, The University of Tokyo
Jerrold Olefsky, UCSD
Martin Myers, University of Michigan
Rudolf Zechner, Karl Franzens University Graz
Jeffrey Gordon, Washington University in St. Louis
Diane Mathis, Harvard University
Gökhan Hotamisligil, Harvard University
Ana Maria Cuervo, Albert Einstein College of Medicine
Philipp Scherer, UTSW
Molecular Cell, 23 December 2011
The cAMP/PKA Pathway Rapidly Activates SIRT1 to Promote Fatty Acid Oxidation Independently of Changes in NAD+
Zachary Gerhart-Hines, John E. Dominy, Sharon M. Blättler, Mark P. Jedrychowski, Alexander S. Banks, Ji-Hong Lim, Helen Chim, Steven P. Gygi, Pere Puigserver
Cell, 23 December 2011
SIRT1 Activates MAO-A in the Brain to Mediate Anxiety and Exploratory Drive
Sergiy Libert, Kelli Pointer, Eric L. Bell, Abhirup Das, Dena E. Cohen, John M. Asara, Karen Kapur, Sven Bergmann, Martin Preisig, Takeshi Otowa et al.
Molecular Cell, 23 December 2011
Tyrosine Phosphorylation of Mitochondrial Pyruvate Dehydrogenase Kinase 1 Is Important for Cancer Metabolism
Taro Hitosugi, Jun Fan, Tae-Wook Chung, Katherine Lythgoe, Xu Wang, Jianxin Xie, Qingyuan Ge, Ting-Lei Gu, Roberto D. Polakiewicz, Johannes L. Roesel et al.

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Cell Metabolism is now publishing papers online in advance of the print version of the journal. Watch this space every Thursday for new articles or updates on the coming issue.
Loss of Autophagy in Pro-opiomelanocortin Neurons Perturbs Axon Growth and Causes Metabolic Dysregulation
Bérengère Coupé, Yuko Ishii, Marcelo O. Dietrich, Masaaki Komatsu, Tamas L. Horvath, and Sebastien G. Bouret
Central Nervous System Mechanisms Linking the Consumption of Palatable High-Fat Diets to the Defense of Greater Adiposity
Karen K. Ryan, Stephen C. Woods, and Randy J. Seeley
AgRP and POMC Neurons Are Hypophysiotropic and Coordinately Regulate Multiple Endocrine Axes in a Larval Teleost
Chao Zhang, Paul M. Forlano, and Roger D. Cone
Adult somatic stem cells (SSCs) are involved in tissue renewal. On pp. 100-109 of this issue, Ahlqvist et al. show that subtle ROS/redox changes, induced by mtDNA mutagenesis, modulate SSC function and contribute to premature aging-related phenotypes. The cover image is a cultured mouse neural stem cell sphere covered by a network of differentiated neurons (green neuronal Tuj1 staining). Nuclei are in blue.
Reactive Oxygen Species Resulting from Mitochondrial Mutation Diminishes Stem and Progenitor Cell Function
B.S. Garrison and D.J. Rossi
Links to Ahlqvist et al.
The Featured Article is freely available to all readers.
I. Shimizu, Y. Yoshida, T. Katsuno, ... I. Komuro, Y. Kobayashi, and T. Minamino
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Heart failure and insulin resistance are often associated. Shimizu et al. show that, in mouse models of heart failure, activation of the sympathetic nervous system promotes lipolysis to upregulate p53 in adipose tissue, leading to inflammation and insulin resistance. |
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Resource Articles highlight significant technical advances and/or major informational databases that are of value and interest to the broad Cell Metabolism readership, and help start addressing important questions in a variety of biomedical research areas.
The mtDNA Mutation Spectrum of the Progeroid Polg Mutator Mouse Includes Abundant Control Region Multimers
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Genetically Encoded Fluorescent Sensors for Intracellular NADH Detection
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