4 January, 2012 Volume 15, Issue 1
Previews
- Treating Obesity Like a Tumor p1
- Reactive Oxygen Species Resulting from Mitochondrial Mutation Diminishes Stem and Progenitor Cell Function p2
- Power Surge: Supporting Cells “Fuel” Cancer Cell Mitochondria p4
- Transgenerational Inheritance of Longevity: Epigenetic Mysteries Abound p6
- IL-6 Muscles In on the Gut and Pancreas to Enhance Insulin Secretion p8
Review
- The Inflammasome Puts Obesity in the Danger Zone p10
Perspective
- Metabolic Disease Drug Discovery— “Hitting the Target” Is Easier Said Than Done p19
Articles
- Srf-Dependent Paracrine Signals Produced by Myofibers Control Satellite Cell-Mediated Skeletal Muscle Hypertrophy p25
- PGRN is a Key Adipokine Mediating High Fat Diet-Induced Insulin Resistance and Obesity through IL-6 in Adipose Tissue p38
- p53-Induced Adipose Tissue Inflammation Is Critically Involved in the Development of Insulin Resistance in Heart Failure p51
- Impaired Generation of 12-Hydroxylated Bile Acids Links Hepatic Insulin Signaling with Dyslipidemia p65
- Acetylation Negatively Regulates Glycogen Phosphorylase by Recruiting Protein Phosphatase 1 p75
- Lysosome-Related Organelles in Intestinal Cells Are a Zinc Storage Site in C. elegans p88
- Somatic Progenitor Cell Vulnerability to Mitochondrial DNA Mutagenesis Underlies Progeroid Phenotypes in Polg Mutator Mice p100
- Glucose-Independent Glutamine Metabolism via TCA Cycling for Proliferation and Survival in B Cells p110
Short Article
- Coordination of Triacylglycerol and Cholesterol Homeostasis by DHR96 and the Drosophila LipA Homolog magro p122
Erratum
- Enteric Neurons and Systemic Signals Couple Nutritional and Reproductive Status with Intestinal Homeostasis p128
Prev Issue
On the cover: Adult somatic stem cells (SSCs) are involved in tissue renewal. On pp. 100–109 of this issue, Ahlqvist et al. show that subtle ROS/redox changes, induced by mtDNA mutagenesis, modulate SSC function and contribute to premature aging-related phenotypes. The cover image is a cultured mouse neural stem cell sphere covered by a network of differentiated neurons (green neuronal Tuj1 staining). Nuclei are in blue.
