The Basics of Sperm Motility
Sperm become motile after entering female reproductive tract. The sperm cell gets alkalized in this process, and Kirichok and colleagues now find that a proton channel in the sperm tail is activated. This channel could be an attractive target to control male fertility. Preview by Sutton and colleagues.

Nucleoporins Take an Inside Job
Nuclear pore complexes (NPCs) mediate transport across the nuclear envelope. The groups of Fornerod and colleagues and Hetzer and colleagues now show that NPCs are also present in the nucleoplasm of fly cells, where they bind to genes and regulate their expression. Preview by Hou and Corces.

p53, This DUB's for You
The tumor suppressor p53 is regulated by ubiquitination, which targets it for degradation. Lou and colleagues now identify USP10 as an enzyme that specifically deubiquitinates p53, thereby counteracting the ubiquitin ligase Mdm2. Preview by Jochemsen and Shiloh.

Protons Away for Sperm Activation!
Human sperm are activated to swim more vigorously once they enter the female reproductive tract. Watch and listen as Lishko and Kirichok take you on a brief, personally guided tour of their discovery of the Hv1 proton channel responsible for sperm activation. Read more in Lishko et al.

A Prion to Remember
It is remarkable that we can remember transient events even years after they happened. Si and colleagues now provide evidence that a protein's prion-like behavior underlies the "marking" of neuronal synapses and allows memories to persist despite continuous protein turnover.

In this PaperClip, Angela Andersen speaks with Kausik Si about the role of self-perpetuating protein conformations in long-term memory.

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Autophagy Encapsulated
Cell's Leading Edge launches a new Primer series with a Primer article by Noboru Mizushima, Tamotsu Yoshimori, and Beth Levine that compares and contrasts assays to measure autophagy.

Methods in Mammalian Autophagy Research
Noboru Mizushima, Tamotsu Yoshimori, and Beth Levine

In our January podcast, we hear from Thomas Nyström (0:48) about daughter yeast cells that retain the fountain of youth thanks to help from their mothers. Next, Gabriela Gibson explains how a singing contest helps mosquitoes find the ideal mate (8:22). And stay tuned for a conversation with Carl Thummel about a nuclear receptor that keeps fruit flies slim (13:51).

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In this PaperClip, Britta Mädge speaks with Richard Marais about the interactions of two oncogenes and the fact that chemotherapy in melanoma in not "one size fits all."

You can listen directly by clicking on the player above. For a complete list of Cell PaperClips, view the archive.

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